A NEW SYNTHESIS OF PHOSPHONIC ACID ESTERS

A Density Functional Theory Study of Structure of Phosphonic Acid

The molecular structure of the stable conformation of phosphonic acid in gas phase has beencomputed by employing complete geometry optimization in Density Functional Theory(DFT) methods. The methods used for calculations are B3LYP, BP86 and B3PW91 that havebeen studied in two series of basis sets: D95** and 6-31+G(d,p) for hydrogen and oxygenatoms; LANL2DZ for phosphorus. Bond lengths and angle...

Enzymatic Synthesis of Sugar Fatty Acid Esters

Enzymatic synthesis of sugar fatty acid esters was performed in an organic solvent using an immobilized Candida antartica lipase and various sugars and oleic acid as substrates. A high solubility of the sugar in the solvent was needed for a high sugar ester yield. Among the sugars and solvents tested in this study, the highest yield (98 %) was obtained when xylitol and 2-methyl 2-butanol were u...

synthesis of heterocyclic esters of caffeic acid using mitsunobu reaction

New strategy for the synthesis of functionalized phosphonic acids

Various approaches leading to mono-, diand poly-functionalized phosphonates as well as phosphoryl heterocycles were reported for the systematic study of relationship between chemical structure and biological activities of this most important class of organophosphorus compounds. Introduction Functionalization of phosphonic acid molecules opens enoi-nious possibilities of structural variation of ...

Synthesis, Evaluation of Anticancer Activity and QSAR Study of Heterocyclic Esters of Caffeic Acid

 Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catecho...